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The 3R allele for this variant is associated with a 24 fold increase in expression of the TYMS enzyme, as a result of the effect of this variant on the translation efficiency of TYMS

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All procedures and manipulations with animals were approved by the Committee for Control over Care and Use of Laboratory Animals of BIBCh RAS and were carried out in accordance with the EU Directive 2010/63/EU for animal experiments and Animal Control and Use Committee (IACUC) protocol number 683/19